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aliskiren and amlodipine

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Pronunciation: AL is KYE ren and am LOE de peen

Brand: Tekamlo

What is the most important information I should know about aliskiren and amlodipine?

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.

You should not take aliskiren and amlodipine if you are also using cyclosporine or itraconazole.

If you have diabetes, you should not use aliskiren and amlodipine together with certain heart or blood pressure medicines (such as Accupril, Benicar, Capoten, Cozaar, Diovan, Lotensin, Mavik, Prinivil, Vasotec, and many others).

What is aliskiren and amlodipine?

Aliskiren is an anti-hypertensive (blood pressure lowering) medication. It works by decreasing substances in the body that narrow blood vessels and raise blood pressure.

Amlodipine is a calcium channel blocker that relaxes (widens) blood vessels and improves blood flow.

Aliskiren and amlodipine is a combination medicine used to treat high blood pressure (hypertension).

Aliskiren and amlodipine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking aliskiren and amlodipine?

You should not take this medicine if you are allergic to aliskiren or amlodipine, or if you are also using cyclosporine or itraconazole.

If you have diabetes, you should not use aliskiren and amlodipine together with certain heart or blood pressure medicines, such as:

  • azilsartan (Edarbi, Edarbyclor), candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro, Avalide), losartan (Cozaar, Hyzaar), olmesartan (Azar, Benicar), valsartan (Diovan, Exforge, Tribenzor), telmisartan (Micardis); or
  • benazepril (Lotensin), captopril (Capoten, Capozide), enalapril (Vasotec, Vasoretic), fosinopril (Monopril), lisinopril (Prinivil, Zestoretic, Zestril), moexipril (Uniretic, Univasc), perindopril (Aceon), quinapril (Accupril, Accuretic), ramipril (Altace), or trandolapril (Mavik, Tarka).

You may also need to avoid taking these medicines with aliskiren and amlodipine if you have kidney disease.

To make sure aliskiren and amlodipine is safe for you, tell your doctor if you have:

  • kidney disease;
  • liver disease;
  • heart disease or prior heart attack;
  • coronary artery disease (hardened arteries);
  • if you are on a low-salt diet; or
  • if you have ever had an allergic reaction to an ACE inhibitor heart or blood pressure medicine (benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, quinapril, ramipril, trandolapril).

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Aliskiren can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

It is not known whether aliskiren and amlodipine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take aliskiren and amlodipine?

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

You may take this medicine with or without food, but take it the same way every time.

You may have very low blood pressure while taking this medicine. Call your doctor if you are sick with vomiting or diarrhea, or if you feel very dizzy.

Your blood pressure will need to be checked often.

Your chest pain may become worse when you first start taking aliskiren and amlodipine, or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.

If you need surgery or medical tests, tell the doctor ahead of time that you are using aliskiren and amlodipine. You may need to stop using the medicine for a short time.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Store in the original container at room temperature, away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking aliskiren and amlodipine?

Do not use potassium supplements or salt substitutes while you are taking aliskiren and amlodipine, unless your doctor has told you to.

Avoid drinking alcohol. It can further lower your blood pressure and may increase some of the side effects of aliskiren and amlodipine.

Avoid taking this medicine with a high-fat meal, which can make it harder for your body to absorb aliskiren.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

What are the possible side effects of aliskiren and amlodipine?

Get emergency medical help if you have signs of an allergic reaction: hives; vomiting, severe stomach pain; dizziness, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • chest pain or pressure, pain spreading to your jaw or shoulder;
  • little or no urination; or
  • high potassium --nausea, slow or unusual heart rate, weakness, loss of movement.

Common side effects may include:

  • swelling in your ankles or feet;
  • dizziness, tired feeling;
  • cough;
  • diarrhea; or
  • flu symptoms (fever, chills, body aches).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect aliskiren and amlodipine?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • cyclosporine;
  • any heart or blood pressure medicines;
  • a diuretic or "water pill";
  • a potassium supplement such as K-Dur, Klor-Con;
  • salt substitutes that contain potassium;
  • antifungal medicine --itraconazole, ketoconazole;
  • cholesterol medication --atorvastatin, simvastatin, Lipitor, Zocor;
  • HIV or AIDS medicine --indinavir, ritonavir, and others; or
  • NSAIDs (nonsteroidal anti-inflammatory drugs) --aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may interact with aliskiren and amlodipine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

our pharmacist can provide more information about aliskiren and amlodipine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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